ArteMedics has developed two biocompatible, biostable soft tissue fillers that they believe will address the durability issues observed with current products used for non-surgical Stress urinary incontinence repair.
Urinary incontinence affects approximately 20% of all neutered female dogs, and is predominantly due to urethral sphincter failure. Traditional therapy includes α-agonist drugs, estrogen compounds, or surgical procedures that improve intrabdominal pressure transmission to the proximal urethra (such as synthetic polymer slings). For patients that fail medical or surgical intervention, there are no effective alternative treatments.
Collafyl and Collafyl Helix can be injected after performing a complete evaluation of the lower urinary and reproductive structures to rule out anatomic causes. A cystoscope will be placed within the proximal urethra to visualize the vesicourethral junction. The recommended site for collagen injection is approximately 1-1.5 cm caudal to the vesicourethral junction. The tip of the needle will be placed immediately below the urethral mucosa into the submucosal layer. The Collafyl or Collafyl Heilix is injected at three to four sites in a circle. The amount of collagen injected at each site is determined visually. The procedure is considered complete when the injection sites appose one another, achieving visual obstruction of the urethral lumen.